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DisProt Region Reference Corresponding author
DP00001Region 1Abramczyk D, Tchorzewski M, Krokowski D, Boguszewska A, Grankowski N. "Overexpression, purification and characterization of the acidic ribosomal P-proteins from Candida albicans." Biochim Biophys Acta. 2004; 1672(3): 214-23., PMID: 15182941  
DP00002 Remacha M, Saenz-Robles MT, Vilella MD, Ballesta JP. "Independent genes coding for three acidic proteins of the large ribosomal subunit from Saccharomyces cerevisiae." J Biol Chem. 1988; 263(19): 9094-9101., PMID: 2837476  
 Region 1Zurdo J, Sanz JM, Gonzalez C, Rico M, Ballesta JP. "The exchangeable yeast ribosomal acidic protein YP2beta shows characteristics of a partly folded state under physiological conditions." Biochemistry. 1997; 36(31): 9625-35., PMID: 9236009  
 Region 1Zurdo J, Gonzalez C, Sanz JM, Rico M, Remacha M, Ballesta JP. "Structural differences between Saccharomyces cerevisiae ribosomal stalk proteins P1 and P2 support their functional diversity." Biochemistry. 2000; 39(30): 8935-43., PMID: 10913306  
DP00003Region 1, Region 2, Region 3Tucker, P., Tsernoglou, D., Tucker, A., Coenjaerts, F., Leenders, H., Vliet, P. "Crystal structure of the adenovirus DNA binding protein reveals a hook-on model for cooperative DNA binding." 1994; 13(13): 2994-3002., PMID: 8039495  
 Region 1, Region 2, Region 3Dekker, J. Kanellopoulos, P. N. van Oosterhout, J. A. Stier, G. Tucker, P. A. van der Vliet, P. C. "ATP-independent DNA unwinding by the adenovirus single-stranded DNA binding protein requires a flexible DNA binding loop." Journal of Molecular Biology. 1998; 277(4): 825-838., PMID: 9545375  
 Region 4, Region 5, Region 6, Region 7Dekker J, Kanellopoulos PN, van Oosterhout JA, Stier G, Tucker PA, van der Vliet PC. "ATP-independent DNA unwinding by the adenovirus single-stranded DNA binding protein requires a flexible DNA binding loop." J Mol Biol. 1998; 277(4): 825-38., PMID: 9545375  
 Region 4, Region 5, Region 6, Region 7Tucker PA, Tsernoglou D, Tucker AD, Coenjaerts FE, Leenders H, van der Vliet PC. "Crystal structure of the adenovirus DNA binding protein reveals a hook-on model for cooperative DNA binding." Embo J. 1994; 13(13): 2994-3002., PMID: 8039495  
 Region 1, Region 2, Region 3, Region 4, Region 5, Region 6, Region 7Tsernoglou D, Tsugita A, Tucker AD, van der Vliet PC. "Characterization of the chymotryptic core of the adenovirus DNA-binding protein." FEBS Lett. 1985; 188(2): 248-52., PMID: 4040872  
DP00004Region 1Johansson, J. Gudmundsson, G. H. Rottenberg, M. E. Berndt, K. D. Agerberth, B. "Conformation-dependent antibacterial activity of the naturally occurring human peptide LL-37." J Biol Chem. 1998; 273(6): 3718-3724., PMID: 9452503  
DP00005 Legault P, Li J, Mogridge J, Kay LE, Greenblatt J. "NMR structure of the bacteriophage lambda N peptide/boxB RNA complex: recognition of a GNRA fold by an arginine-rich motif." Cell. 1998; 93(2): 289-99., PMID: 9568720  
  Van Gilst MR, von Hippel PH. "Assembly of the N-dependent antitermination complex of phage lambda: NusA and RNA bind independently to different unfolded domains of the N protein." J Mol Biol. 1997; 274(2): 160-73., PMID: 9398524  
 Region 1Mogridge J, Legault P, Li J, Van Oene MD, Kay LE, Greenblatt J. "Independent ligand-induced folding of the RNA-binding domain and two functionally distinct antitermination regions in the phage lambda N protein." Mol Cell. 1998; 1(2): 265-75., PMID: 9659923  
DP00006Region 1Stellwagen E, Rysavy R, Babul G. "The conformation of horse heart apocytochrome c." J Biol Chem. 1972; 247(24): 8074-7., PMID: 4344990  
DP00007 Barzilay G, Hickson ID. "Structure and function of apurinic/apyrimidinic endonucleases." Bioessays. 1995; 17(8): 713-719., PMID: 7661852  
  Robson CN, Hickson ID. "Isolation of cDNA clones encoding a human apurinic/apyrimidinic endonuclease that corrects DNA repair and mutagenesis defects in E. coli xth (exonuclease III) mutants." Nucleic Acids Res. 1991; 19(20): 5519-5523., PMID: 1719477  
  Robson CN, Hochhauser D, Craig R, Rack K, Buckle VJ, Hickson ID. "Structure of the human DNA repair gene HAP1 and its localisation to chromosome 14q 11.2-12." Nucleic Acids Res. 1992; 20(17): 4417-4421., PMID: 1383925  
 Region 2, Region 6Gorman MA, Morera S, Rothwell DG, de La Fortelle E, Mol CD, Tainer JA, Hickson ID, Freemont PS. "The crystal structure of the human DNA repair endonuclease HAP1 suggests the recognition of extra-helical deoxyribose at DNA abasic sites." Embo J. 1997; 16(21): 6548-58., PMID: 9351835  
 Region 1, Region 3, Region 4, Region 5Beernink PT, Segelke BW, Hadi MZ, Erzberger JP, Wilson DM 3rd, Rupp B. "Two divalent metal ions in the active site of a new crystal form of human apurinic/apyrimidinic endonuclease, Ape1: implications for the catalytic mechanism." J Mol Biol. 2001; 307(4): 1023-34., PMID: 11286553  
DP00008Region 1Chang JF, Phillips K, Lundback T, Gstaiger M, Ladbury JE, Luisi B. "Oct-1 POU and octamer DNA co-operate to recognise the Bob-1 transcription co-activator via induced folding." J Mol Biol. 1999; 288(5): 941-52., PMID: 10329190  
DP00009 Burley SK. "Picking up the TAB." Nature. 1996; 381(6578): 112-3., PMID: 8610004  
 Region 1Tan S, Hunziker Y, Sargent DF, Richmond TJ. "Crystal structure of a yeast TFIIA/TBP/DNA complex." Nature. 1996; 381(6578): 127-51., PMID: 8610010  
DP00011 Bidwell LM, McManus ME, Gaedigk A, Kakuta Y, Negishi M, Pedersen L, Martin JL. "Crystal structure of human catecholamine sulfotransferase." J Mol Biol. 1999; 293(3): 521-530., PMID: 10543947  
  Dajani R, Cleasby A, Neu M, Wonacott AJ, Jhoti H, Hood AM, Modi S, Hersey A, Taskinen J, Cooke RM, Manchee GR, Coughtrie MW. "X-ray crystal structure of human dopamine sulfotransferase, SULT1A3. Molecular modeling and quantitative structure-activity relationship analysis demonstrate a molecular basis for sulfotransferase substrate specificity." J Biol Chem. 1999; 274(53): 37862-37868., PMID: 10608851  
 Region 1, Region 2, Region 3, Region 4, Region 5, Region 6, Region 7, Region 8, Region 9, Region 10Bidwell LM, McManus ME, Gaedigk A, Kakuta Y, Negishi M, Pedersen L, Martin JL. "Crystal structure of human catecholamine sulfotransferase." J Mol Biol. 1999; 293(3): 521-530., PMID: 10543947  
DP00012Region 1Ostedgaard Lynda S, Baldursson Olafur, Vermeer Daniel W, Welsh Michael J, Robertson Andrew W. "A functional R domain from cystic fibrosis transmembrane conductance regulator is predominantly unstructured in solution." PNAS. 2000; 97(10): 5657-5662. 
DP00013Region 1Lapthorn AJ, Harris DC, Littlejohn A, Lustbader JW, Canfield RE, Machin KJ, Morgan FJ, Isaacs NW. "Crystal structure of human chorionic gonadotropin." Nature. 1994; 369(6480): 455-61., PMID: 8202136  
DP00014 Barghorn S, Davies P, Mandelkow E. "Tau paired helical filaments from Alzheimer's disease brain and assembled in vitro are based on beta-structure in the core domain." Biochemistry. 2004; 43(6): 1694-1703., PMID: 14769047 mand@mpasmb.desy.de
  Tsuruta JK, Wong K, Fritz IB, Griswold MD. "Structural analysis of sulphated glycoprotein 2 from amino acid sequence. Relationship to clusterin and serum protein 40,40." Biochem J. 1990; 268(3): 571-8., PMID: 2363694  
 Region 1, Region 2, Region 3Bailey RW, Dunker AK, Brown CJ, Garner EC, Griswold MD. "Clusterin, a binding protein with a molten globule-like region." Biochemistry. 2001; 40(39): 11828-40., PMID: 11570883  
DP00015Region 1Knighton DR, Zheng JH, Ten Eyck LF, Xuong NH, Taylor SS, Sowadski JM. "Structure of a peptide inhibitor bound to the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase." Science. 1991; 253(5018): 414-20., PMID: 1862343  
 Region 1Thomas J, Van Patten SM, Howard P, Day KH, Mitchell RD, Sosnick T, Trewhella J, Walsh DA, Maurer RA. "Expression in Escherichia coli and characterization of the heat-stable inhibitor of the cAMP-dependent protein kinase." J Biol Chem. 1991; 266(17): 10906-11., PMID: 2040607  
DP00016 Harper JW, Adami GR, Wei N, Keyomarsi K, Elledge SJ. "The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases." Cell. 1993; 75(4): 805-16., PMID: 8242751  
 Region 1Kriwacki RW, Hengst L, Tennant L, Reed SI, Wright PE. "Structural studies of p21Waf1/Cip1/Sdi1 in the free and Cdk2-bound state: conformational disorder mediates binding diversity." Proc Natl Acad Sci U S A. 1996; 93(21): 11504-9., PMID: 8876165  
 Region 1Kriwacki RW, Wu J, Tennant L, Wright PE, Siuzdak G. "Probing protein structure using biochemical and biophysical methods. Proteolysis, matrix-assisted laser desorption/ionization mass spectrometry, high-performance liquid chromatography and size-exclusion chromatography of p21Waf1/Cip1/Sdi1." J Chromatogr A. 1997; 777(1): 23-30., PMID: 9297835  
DP00017Region 1, Region 2Adkins JN, Lumb KJ. "Intrinsic structural disorder and sequence features of the cell cycle inhibitor p57Kip2." Proteins. 2002; 46(1): 1-7., PMID: 11746698  
 Region 1, Region 2Dynlacht BD, Ngwu C, Winston J, Swindell EC, Elledge SJ, Harlow E, Harper JW. "Purification and analysis of CIP/KIP proteins." Methods Enzymol. 1997; 283: 230-44., PMID: 9251023  
DP00018Region 1Lacy ER, Filippov I, Lewis WS, Otieno S, Xiao L, Weiss S, Hengst L, Kriwacki RW. "p27 binds cyclin-CDK complexes through a sequential mechanism involving binding-induced protein folding." Nat Struct Mol Biol. 2004; 11(4): 358-64., PMID: 15024385  
 Region 1Russo AA, Jeffrey PD, Patten AK, Massague J, Pavletich NP. "Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex." Nature. 1996; 382(6589): 325-31., PMID: 8684460  
DP00019Region 1Iwata S, Lee JW, Okada K, Lee JK, Iwata M, Rasmussen B, Link TA, Ramaswamy S, Jap BK. "Complete structure of the 11-subunit bovine mitochondrial cytochrome bc1 complex." Science. 1998; 281(5373): 64-71., PMID: 9651245  
DP00020Region 1Konig P, Giraldo R, Chapman L, Rhodes D. "The crystal structure of the DNA-binding domain of yeast RAP1 in complex with telomeric DNA." Cell. 1996; 85(1): 125-36., PMID: 8620531  
DP00021 AEvarsson A, Brazhnikov E, Garber M, Zheltonosova J, Chirgadze Y, al-Karadaghi S, Svensson LA, Liljas A. "Three-dimensional structure of the ribosomal translocase: elongation factor G from Thermus thermophilus." Embo J. 1994; 13(16): 3669-77., PMID: 8070397  
 Region 1, Region 2Laurberg M, Kristensen O, Martemyanov K, Gudkov AT, Nagaev I, Hughes D, Liljas A. "Structure of a mutant EF-G reveals domain III and possibly the fusidic acid binding site." J Mol Biol. 2000; 303(4): 593-603., PMID: 11054294  
DP00022Region 1Eom J, Baker WR, Kintanar A, Wurtele ES. "The embryo-specific EMB-1 protein of Daucus carota is flexible and unstructured in solution." Plant Science. 1996; 115: 17-24. 
DP00023Region 1, Region 2Azzi A, Rehse PH, Zhu DW, Campbell RL, Labrie F, Lin SX. "Crystal structure of human estrogenic 17 beta-hydroxysteroid dehydrogenase complexed with 17 beta-estradiol." Nat Struct Biol. 1996; 3(8): 665-668., PMID: 8756321  
 Region 3, Region 4, Region 5, Region 6, Region 7, Region 8, Region 9Breton R, Housset D, Mazza C, Fontecilla-Camps JC. "The structure of a complex of human 17beta-hydroxysteroid dehydrogenase with estradiol and NADP+ identifies two principal targets for the design of inhibitors." Structure. 1996; 4(8): 905-915., PMID: 8805577  
 Region 5, Region 19Gangloff A, Shi R, Nahoum V, Lin SX. "Pseudo-symmetry of C19 steroids, alternative binding orientations, and multispecificity in human estrogenic 17beta-hydroxysteroid dehydrogenase." Faseb J. 2003; 17(2): 274-276., PMID: 12490543  
 Region 1Ghosh D, Pletnev VZ, Zhu DW, Wawrzak Z, Duax WL, Pangborn W, Labrie F, Lin SX. "Structure of human estrogenic 17 beta-hydroxysteroid dehydrogenase at 2.20 A resolution." Structure. 1995; 3(5): 503-513., PMID: 7663947  
 Region 1, Region 18Han Q, Campbell RL, Gangloff A, Huang YW, Lin SX. "Dehydroepiandrosterone and dihydrotestosterone recognition by human estrogenic 17beta-hydroxysteroid dehydrogenase. C-18/c-19 steroid discrimination and enzyme-induced strain." J Biol Chem. 2000; 275(2): 1105-1111., PMID: 10625652  
 Region 5Qiu W, Campbell RL, Gangloff A, Dupuis P, Boivin RP, Tremblay MR, Poirier D, Lin SX. "A concerted, rational design of type 1 17beta-hydroxysteroid dehydrogenase inhibitors: estradiol-adenosine hybrids with high affinity." Faseb J. 2002; 16(13): 1829-1831., PMID: 12223444  
 Region 1, Region 17Sawicki MW, Erman M, Puranen T, Vihko P, Ghosh D. "Structure of the ternary complex of human 17beta-hydroxysteroid dehydrogenase type 1 with 3-hydroxyestra-1,3,5,7-tetraen-17-one (equilin) and NADP+." Proc Natl Acad Sci U S A. 1999; 96(3): 840-845., PMID: 9927655  
 Region 5, Region 10, Region 11, Region 12, Region 13, Region 14, Region 15, Region 16Mazza C, Breton R, Housset D, Fontecilla-Camps JC. "Unusual charge stabilization of NADP+ in 17beta-hydroxysteroid dehydrogenase." J Biol Chem. 1998; 273(14): 8145-8152., PMID: 9525918  
DP00024Region 1Pahel G, Aulabaugh A, Short SA, Barnes JA, Painter GR, Ray P, Phelps WC. "Structural and functional characterization of the HPV16 E7 protein expressed in bacteria." J Biol Chem. 1993; 268(34): 26018-25., PMID: 8245034  
DP00025Region 1Penkett CJ, Redfield C, Dodd I, Hubbard J, McBay DL, Mossakowska DE, Smith RA, Dobson CM, Smith LJ. "NMR analysis of main-chain conformational preferences in an unfolded fibronectin-binding protein." J Mol Biol. 1997; 274(2): 152-9., PMID: 9398523  
DP00026Region 1, Region 2Vonderviszt F, Kanto S, Aizawa S, Namba K. "Terminal regions of flagellin are disordered in solution." J Mol Biol. 1989; 209(1): 127-33., PMID: 2810365  
DP00027Region 1Daughdrill GW, Chadsey MS, Karlinsey JE, Hughes KT, Dahlquist FW. "The C-terminal half of the anti-sigma factor, FlgM, becomes structured when bound to its target, sigma 28." Nat Struct Biol. 1997; 4(4): 285-91., PMID: 9095196  
DP00028Region 1Fletcher CM, Wagner G. "The interaction of eIF4E with 4E-BP1 is an induced fit to a completely disordered protein." Protein Sci. 1998; 7(7): 1639-42., PMID: 9684899  
DP00029 Lin LF, Doherty DH, Lile JD, Bektesh S, Collins F. "GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons." Science. 1993; 260(5111): 1130-2., PMID: 8493557  
 Region 1, Region 3, Region 4Eigenbrot C, Gerber N. "X-ray structure of glial cell-derived neurotrophic factor at 1.9 A resolution and implications for receptor binding." Nat Struct Biol. 1997; 4(6): 435-8., PMID: 9187648  
 Region 1, Region 2Eketjall S, Fainzilber M, Murray-Rust J, Ibanez CF. "Distinct structural elements in GDNF mediate binding to GFRalpha1 and activation of the GFRalpha1-c-Ret receptor complex." Embo J. 1999; 18(21): 5901-10., PMID: 10545102  
DP00030 Hollenberg SM, Weinberger C, Ong ES, Cerelli G, Oro A, Lebo R, Thompson EB, Rosenfeld MG, Evans RM. "Primary structure and expression of a functional human glucocorticoid receptor cDNA." Nature. 1985; 318(6047): 635-41., PMID: 2867473  
 Region 1, Region 2Baskakov IV, Kumar R, Srinivasan G, Ji YS, Bolen DW, Thompson EB. "Trimethylamine N-oxide-induced cooperative folding of an intrinsically unfolded transcription-activating fragment of human glucocorticoid receptor." J Biol Chem. 1999; 274(16): 10693-10696., PMID: 10196139 bthompso@utmb.edu
 Region 1Dahlman-Wright K, Baumann H, McEwan IJ, Almlof T, Wright AP, Gustafsson JA, Hard T. "Structural characterization of a minimal functional transactivation domain from the human glucocorticoid receptor." Proc Natl Acad Sci U S A. 1995; 92(5): 1699-1703., PMID: 7878043  
 Region 1Li G, Wang S, Gelehrter TD. "Identification of glucocorticoid receptor domains involved in transrepression of transforming growth factor-beta action." J Biol Chem. 2003; 278(43): 41779-41788., PMID: 12902338  
DP00031Region 1Huang Y, Komoto J, Konishi K, Takata Y, Ogawa H, Gomi T, Fujioka M, Takusagawa F. "Mechanisms for auto-inhibition and forced product release in glycine N-methyltransferase: crystal structures of wild-type, mutant R175K and S-adenosylhomocysteine-bound R175K enzymes." J Mol Biol. 2000; 298(1): 149-62., PMID: 10756111  
DP00032 Mazauric MH, Keith G, Logan D, Kreutzer R, Giege R, Kern D. "Glycyl-tRNA synthetase from Thermus thermophilus--wide structural divergence with other prokaryotic glycyl-tRNA synthetases and functional inter-relation with prokaryotic and eukaryotic glycylation systems." Eur J Biochem. 1998; 251(3): 744-57., PMID: 9490048  
 Region 1Arnez JG, Dock-Bregeon AC, Moras D. "Glycyl-tRNA synthetase uses a negatively charged pit for specific recognition and activation of glycine." J Mol Biol. 1999; 286(5): 1449-59., PMID: 10064708  
 Region 1Logan DT, Mazauric MH, Kern D, Moras D. "Crystal structure of glycyl-tRNA synthetase from Thermus thermophilus." Embo J. 1995; 14(17): 4156-67., PMID: 7556056  
DP00033 Clackson T, Wells JA. "A hot spot of binding energy in a hormone-receptor interface." Science. 1995; 267(5196): 383-386., PMID: 7529940  
  Clackson T, Ultsch MH, Wells JA, de Vos AM. "Structural and functional analysis of the 1:1 growth hormone:receptor complex reveals the molecular basis for receptor affinity." J Mol Biol. 1998; 277(5): 1111-1128., PMID: 9571026  
  de Vos AM, Ultsch M, Kossiakoff AA. "Human growth hormone and extracellular domain of its receptor: crystal structure of the complex." Science. 1992; 255(5042): 306-312., PMID: 1549776  
  Sundstrom M, Lundqvist T, Rodin J, Giebel LB, Milligan D, Norstedt G. "Crystal structure of an antagonist mutant of human growth hormone, G120R, in complex with its receptor at 2.9 A resolution." J Biol Chem. 1996; 271(50): 32197-32203., PMID: 8943276  
  Fuh G, Mulkerrin MG, Bass S, McFarland N, Brochier M, Bourell JH, Light DR, Wells JA. "The human growth hormone receptor. Secretion from Escherichia coli and disulfide bonding pattern of the extracellular binding domain." J Biol Chem. 1990; 265(6): 3111-3115., PMID: 2406245  
 Region 1, Region 2, Region 3, Region 4, Region 5, Region 6, Region 11, Region 12Clackson T, Ultsch MH, Wells JA, de Vos AM. "Structural and functional analysis of the 1:1 growth hormone:receptor complex reveals the molecular basis for receptor affinity." J Mol Biol. 1998; 277(5): 1111-1128., PMID: 9571026  
 Region 5, Region 6, Region 13, Region 14, Region 15, Region 16, Region 17, Region 18de Vos AM, Ultsch M, Kossiakoff AA. "Human growth hormone and extracellular domain of its receptor: crystal structure of the complex." Science. 1992; 255(5042): 306-312., PMID: 1549776  
 Region 7, Region 8, Region 9, Region 10Sundstrom M, Lundqvist T, Rodin J, Giebel LB, Milligan D, Norstedt G. "Crystal structure of an antagonist mutant of human growth hormone, G120R, in complex with its receptor at 2.9 A resolution." J Biol Chem. 1996; 271(50): 32197-32203., PMID: 8943276  
DP00034Region 1Holliger P, Riechmann L, Williams RL. "Crystal structure of the two N-terminal domains of g3p from filamentous phage fd at 1.9 A: evidence for conformational lability." J Mol Biol. 1999; 288(4): 649-57., PMID: 10329170  
 Region 1Nilsson N, Malmborg AC, Borrebaeck CA. "The phage infection process: a functional role for the distal linker region of bacteriophage protein 3." J Virol. 2000; 74(9): 4229-35., PMID: 10756036  
DP00035Region 1Coleman DE, Berghuis AM, Lee E, Linder ME, Gilman AG, Sprang SR. "Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis." Science. 1994; 265(5177): 1405-12., PMID: 8073283  
DP00036 Jakobsen BK, Pelham HR. "A conserved heptapeptide restrains the activity of the yeast heat shock transcription factor." Embo J. 1991; 10(2): 369-75., PMID: 1899375  
 Region 1Cho HS, Liu CW, Damberger FF, Pelton JG, Nelson HC, Wemmer DE. "Yeast heat shock transcription factor N-terminal activation domains are unstructured as probed by heteronuclear NMR spectroscopy." Protein Sci. 1996; 5(2): 262-9., PMID: 8745404  
 Region 2, Region 3Damberger FF, Pelton JG, Harrison CJ, Nelson HC, Wemmer DE. "Solution structure of the DNA-binding domain of the heat shock transcription factor determined by multidimensional heteronuclear magnetic resonance spectroscopy." Protein Sci. 1994; 3(10): 1806-1821., PMID: 7849597  
 Region 4Harrison CJ, Bohm AA, Nelson HC. "Crystal structure of the DNA binding domain of the heat shock transcription factor." Science. 1994; 263(5144): 224-7., PMID: 8284672  
DP00037Region 1, Region 2, Region 3, Region 4, Region 5Mizohata E, Sakai H, Fusatomi E, Terada T, Murayama K, Shirouzu M, Yokoyama S. "Crystal Structure of an Archaeal Peroxiredoxin from the Aerobic Hyperthermophilic Crenarchaeon Aeropyrum pernix K1." J Mol Biol. 2005., PMID: 16214169  
DP00038Region 1Cary PD, Crane-Robinson C, Bradbury EM, Dixon GH. "Structural studies of the non-histone chromosomal proteins HMG-T and H6 from trout testis." Eur J Biochem. 1981; 119(3): 545-551., PMID: 6273163  
DP00039Region 1Abercrombie BD, Kneale GG, Crane-Robinson C, Bradbury EM, Goodwin GH, Walker JM, Johns EW. "Studies on the conformational properties of the high-mobility-group chromosomal protein HMG 17 and its interaction with DNA." Eur J Biochem. 1978; 84(1): 173-177., PMID: 565710  
DP00040Region 1Munshi N, Agalioti T, Lomvardas S, Merika M, Chen G, Thanos D. "Coordination of a transcriptional switch by HMGI(Y) acetylation." Science. 2001; 293(5532): 1133-1136., PMID: 11498590  
 Region 1Pierantoni GM, Fedele M, Pentimalli F, Benvenuto G, Pero R, Viglietto G, Santoro M, Chiariotti L, Fusco A. "High mobility group I (Y) proteins bind HIPK2, a serine-threonine kinase protein which inhibits cell growth." Oncogene. 2001; 20(43): 6132-6141., PMID: 11593421  
 Region 1Wang, D. Z. Ray, P. Boothby, M. "Interleukin 4-inducible phosphorylation of HMG-I(Y) is inhibited by rapamycin." J Biol Chem. 1995; 270(39): 22924-22932., PMID: 7559428  
 Region 1Reeves, R. Nissen, M. S. "Purification and assays for high mobility group HMG-I(Y) protein function." Methods of Enzymology. 1996; 304: 155-188., PMID: 10372360  
DP00041 Cary PD, Crane-Robinson C, Bradbury EM, Dixon GH. "Structural studies of the non-histone chromosomal proteins HMG-T and H6 from trout testis." Eur J Biochem. 1981; 119(3): 545-551., PMID: 6273163  
  Pentecost BT, Wright JM, Dixon GH. "Isolation and sequence of cDNA clones coding for a member of the family of high mobility group proteins (HMG-T) in trout and analysis of HMG-T-mRNA's in trout tissues." Nucleic Acids Res. 1985; 13(13): 4871-4888., PMID: 4022777  
  Watson DC, Peters EH, Dixon GH. "The purification, characterization and partial sequence determination of a trout testis non-histone protein, HMG-T." Eur J Biochem. 1977; 74(1): 53-60., PMID: 852459  
  Watson DC, Dixon GH. "Amino acid sequence homologies between the high-mobility-group proteins, HMG-T from trout testis and HMG-1 and -2 from calf thymus: is the poly-aspartic-glutamic acid polypeptide within the main chain?" Biosci Rep. 1981; 1(2): 167-175., PMID: 6117336  
  Stros M, Nishikawa S, Dixon GH. "cDNA sequence and structure of a gene encoding trout testis high-mobility-group-1 protein." Eur J Biochem. 1994; 225(2): 581-91., PMID: 7957172  
 Region 1Cary, P. D. Crane-Robinson, C. Bradbury, E. M. Dixon, G. H. "Structural studies of the non-histone chromosomal proteins HMG-T and H6 from trout testis." Eur J Biochem. 1981; 119(3): 545-551., PMID: 6273163  
DP00042Region 1Cary PD, Crane-Robinson C, Bradbury EM, Dixon GH. "Structural studies of the non-histone chromosomal proteins HMG-T and H6 from trout testis." Eur J Biochem. 1981; 119(3): 545-551., PMID: 6273163  
DP00043 Postle K, Good RF. "DNA sequence of the Escherichia coli tonB gene." Proc Natl Acad Sci U S A. 1983; 80(17): 5235-9., PMID: 6310567  
 Region 1Peacock RS, Weljie AM, Howard SP, Price FD, and Vogel HJ. "The Solution Structure of the C-terminal Domain of TonB and Interaction Studies with TonB Box Peptides." J. Mol. Biol.. 2005; 345: 1185-1197., PMID: 15644214  
DP00044 Ramakrishnan V, Finch JT, Graziano V, Lee PL, Sweet RM. "Crystal structure of globular domain of histone H5 and its implications for nucleosome binding." Nature. 1993; 362(6417): 219-223., PMID: 8384699  
 Region 1, Region 2, Region 3Graziano, V. Gerchman, S. E. Wonacott, A. J. Sweet, R. M. Wells, J. R. White, S. W. Ramakrishnan, V. "Crystallization of the globular domain of histone H5." J Mol Biol. 1990; 212(2): 253-257., PMID: 2181148  
DP00045Region 1, Region 2Focia PJ, Craig SP 3rd, Nieves-Alicea R, Fletterick RJ, Eakin AE. "A 1.4 A crystal structure for the hypoxanthine phosphoribosyltransferase of Trypanosoma cruzi." Biochemistry. 1998; 37(43): 15066-15075., PMID: 9790669  
DP00046 Kobielak K, Kobielak A, Trzeciak WH. "Cloning of the lymphoid enhancer binding factor-1 (Lef-1) cDNA from rat kidney: homology to the mouse sequence." Acta Biochim Pol. 1999; 46(4): 885-888., PMID: 10824856  
 Region 1Love JJ, Li X, Case DA, Giese K, Grosschedl R, Wright PE. "Structural basis for DNA bending by the architectural transcription factor LEF-1." Nature. 1995; 376(6543): 791-795., PMID: 7651541  
DP00047Region 1Polverini, E. Fasano, A. Zito, F. Riccio, P. Cavatorta, P. "Conformation of bovine myelin basic protein purified with bound lipids." Eur Biophys J. 1999; 28(4): 351-355., PMID: 10394626  
DP00048Region 1, Region 2, Region 3Arold S, Franken P, Strub MP, Hoh F, Benichou S, Benarous R, Dumas C. "The crystal structure of HIV-1 Nef protein bound to the Fyn kinase SH3 domain suggests a role for this complex in altered T cell receptor signaling." Structure (Camb). 1997; 5(10): 1361-1372., PMID: 9351809  
 Region 4, Region 5, Region 6, Region 7Arold ST, Baur AS. "Dynamic Nef and Nef dynamics: how structure could explain the complex activities of this small HIV protein." Trends Biochem Sci. 2001; 26(6): 356-363., PMID: 11406408  
DP00049 Jiang Y, Yu VC, Buchholz F, O'Connell S, Rhodes SJ, Candeloro C, Xia YR, Lusis AJ, Rosenfeld MG. "A novel family of Cys-Cys, His-Cys zinc finger transcription factors expressed in developing nervous system and pituitary gland." J Biol Chem. 1996; 271(18): 10723-10730., PMID: 8631881  
 Region 1Berkovits, H. J. Berg, J. M. "Metal and DNA binding properties of a two-domain fragment of neural zinc finger factor 1, a CCHC-type zinc binding protein." Biochemistry. 1999; 38(51): 16826-16830., PMID: 10606515  
DP00050Region 1Julien JP, Cote F, Beaudet L, Sidky M, Flavell D, Grosveld F, Mushynski W. "Sequence and structure of the mouse gene coding for the largest neurofilament subunit." Gene. 1988; 68(2): 307-314., PMID: 3220257  
 Region 1Brown, H. G. Hoh, J. H. "Entropic exclusion by neurofilament sidearms: a mechanism for maintaining interfilament spacing." Biochemistry. 1997; 36(49): 15035-15040., PMID: 9424114  
 Region 1Hoh, J. H. "Functional protein domains from the thermally driven motion of polypeptide chains: a proposal." Protein Sci. 1998; 32(2): 223-228., PMID: 9714161  
DP00051Region 1, Region 2, Region 3, Region 4Grishin NV, Osterman AL, Brooks HB, Phillips MA, Goldsmith EJ. "X-ray structure of ornithine decarboxylase from Trypanosoma brucei: the native structure and the structure in complex with alpha-difluoromethylornithine." Biochemistry. 1999; 38(46): 15174-15184., PMID: 10563800  
 Region 5, Region 6, Region 7, Region 8Jackson LK, Brooks HB, Osterman AL, Goldsmith EJ, Phillips MA. "Altering the reaction specificity of eukaryotic ornithine decarboxylase." Biochemistry. 2000; 39(37): 11247-11257., PMID: 10985770  
 Region 1, Region 2, Region 3, Region 4Jancarik, J. Kim, S.H. "Sparse matrix sampling: a screening method for crystallization of proteins." Journal of Applied Crystallography. 1991; 24: 409-411. 
DP00052Region 1Engel J, Taylor W, Paulsson M, Sage H, Hogan B. "Calcium binding domains and calcium-induced conformational transition of SPARC/BM-40/osteonectin, an extracellular glycoprotein expressed in mineralized and nonmineralized tissues." Biochemistry. 1987; 26(22): 6958-6965., PMID: 3427055  
DP00053Region 1Goldgur Y, Mosyak L, Reshetnikova L, Ankilova V, Lavrik O, Khodyreva S, Safro M. "The crystal structure of phenylalanyl-tRNA synthetase from thermus thermophilus complexed with cognate tRNAPhe." Structure. 1997; 5(1): 59-68., PMID: 9016717  
 Region 1Mosyak L, Reshetnikova L, Goldgur Y, Delarue M, Safro MG. "Structure of phenylalanyl-tRNA synthetase from Thermus thermophilus." Nat Struct Biol. 1995; 2(7): 537-47., PMID: 7664121  
DP00054 Castellino AM, Parker GJ, Boronenkov IV, Anderson RA, Chao MV. "A novel interaction between the juxtamembrane region of the p55 tumor necrosis factor receptor and phosphatidylinositol-4-phosphate 5-kinase." J Biol Chem. 1997; 272(9): 5861-5870., PMID: 9038203  
 Region 3, Region 4Rao VD, Misra S, Boronenkov IV, Anderson RA, Hurley JH. "Structure of type IIbeta phosphatidylinositol phosphate kinase: a protein kinase fold flattened for interfacial phosphorylation." Cell. 1998; 94(6): 829-839., PMID: 9753329  
 Region 1, Region 2Rao, V. D. Misra, S. Boronenkov, I. V. Anderson, R. A. Hurley, J. H. "Structure of type IIbeta phosphatidylinositol phosphate kinase: a protein kinase fold flattened for interfacial phosphorylation." Cell. 1998; 94(6): 829-839., PMID: 9753329  
DP00055Region 1, Region 5, Region 6Essen LO, Perisic O, Cheung R, Katan M, Williams RL. "Crystal structure of a mammalian phosphoinositide-specific phospholipase C delta." Nature. 1996; 380(6575): 595-602., PMID: 8602259  
 Region 1, Region 2, Region 3, Region 4, Region 7Grobler JA, Essen LO, Williams RL, Hurley JH. "C2 domain conformational changes in phospholipase C-delta 1." Nat Struct Biol. 1996; 3(9): 788-95., PMID: 8784353  
DP00057Region 1Gatewood JM, Schroth GP, Schmid CW, Bradbury EM. "Zinc-induced secondary structure transitions in human sperm protamines." J Biol Chem. 1990; 265(33): 20667-72., PMID: 2243113  
 Region 1Nakano M, Kasai K, Yoshida K, Tanimoto T, Tamaki Y, Tobita T. "Conformation of the fowl protamine, galline, and its binding properties to DNA." J Biochem (Tokyo). 1989; 105(1): 133-7., PMID: 2738040  
DP00058Region 1Gast K, Damaschun H, Eckert K, Schulze-Forster K, Maurer HR, Muller-Frohne M, Zirwer D, Czarnecki J, Damaschun G. "Prothymosin alpha: a biologically active protein with random coil conformation." Biochemistry. 1995; 34(40): 13211-8., PMID: 7548085  
DP00060Region 1, Region 2Gong W, O'Gara M, Blumenthal RM, Cheng X. "Structure of pvu II DNA-(cytosine N4) methyltransferase, an example of domain permutation and protein fold assignment." Nucleic Acids Res. 1997; 25(14): 2702-15., PMID: 9207015  
DP00061Region 1Jacobs DM, Lipton AS, Isern NG, Daughdrill GW, Lowry DF, Gomes X, Wold MS. "Human replication protein A: global fold of the N-terminal RPA-70 domain reveals a basic cleft and flexible C-terminal linker." J Biomol NMR. 1999; 14(4): 321-31., PMID: 10526407  
DP00062 Mangelsdorf DJ, Ong ES, Dyck JA, Evans RM. "Nuclear receptor that identifies a novel retinoic acid response pathway." Nature. 1990; 345(6272): 224-9., PMID: 2159111  
 Region 1, Region 2, Region 3, Region 4, Region 5Holmbeck SM, Foster MP, Casimiro DR, Sem DS, Dyson HJ, Wright PE. "High-resolution solution structure of the retinoid X receptor DNA-binding domain." J Mol Biol. 1998; 281(2): 271-84., PMID: 9698548  
 Region 1, Region 2, Region 3, Region 4, Region 5Holmbeck SM, Dyson HJ, Wright PE. "DNA-induced conformational changes are the basis for cooperative dimerization by the DNA binding domain of the retinoid X receptor." J Mol Biol. 1998; 284(3): 533-9., PMID: 9826495  
DP00063 Chatterjee TK, Fisher RA. "Novel alternative splicing and nuclear localization of human RGS12 gene products." J Biol Chem. 2000; 275(38): 29660-71., PMID: 10869340  
  Moy FJ, Chanda PK, Cockett MI, Edris W, Jones PG, Mason K, Semus S, Powers R. "NMR structure of free RGS4 reveals an induced conformational change upon binding Galpha." Biochemistry. 2000; 39(24): 7063-73., PMID: 10852703  
 Region 1, Region 2Tesmer JJ, Berman DM, Gilman AG, Sprang SR. "Structure of RGS4 bound to AlF4--activated G(i alpha1): stabilization of the transition state for GTP hydrolysis." Cell. 1997; 89(2): 251-61., PMID: 9108480  
DP00064 Abad-Zapatero C, Abdel-Meguid S, Johnson JE, Leslie AGW, Rayment I, Rossmann MG, Suck Dietrich, Tsukihara T. "Structure of southern bean mosaid virus at 2.8 A resolution." Nature. 1980; 286: 33-39. 
  Hermodson MA, Abad-Zapatero C, Abdel-Meguid S, Pundak S, Rossmann MG, Tremaine J. "Amino acid sequence of southern bean mosaic virus coat protein and its relation to the three-dimensional structure of the virus." Virology. 1982; 119: 133-149. 
 Region 1, Region 2, Region 3, Region 8, Region 9Hermodson MA, Abad-Zapatero C, Abdel-Meguid S, Pundak S, Rossmann MG, Tremaine J. "Amino acid sequence of southern bean mosaic virus coat protein and its relation to the three-dimensional structure of the virus." Virology. 1982; 119: 133-149. 
 Region 1, Region 2, Region 3, Region 4, Region 5, Region 6, Region 7, Region 8, Region 9Rossmann MG, Abad-Zapatero C, Hermodson MA, Erickson JW. "Subunit interactions in southern bean mosaic virus." J Mol Biol. 1983; 166(1): 37-73., PMID: 6854633  
 Region 4, Region 5, Region 6Rossmann MG, Abad-Zapatero C, Erickson JW, Savithri HS. "RNA-protein interactions in some small plant viruses." J Biomol Struct Dyn. 1983; 1(2): 565-79., PMID: 6401119  
 Region 7Silva AM, Rossmann MG. "Refined structure of southern bean mosaic virus at 2.9 A resolution." J Mol Biol. 1987; 197(1): 69-87., PMID: 3681993  
DP00065Region 1Josefsson E, O'Connell D, Foster TJ, Durussel I, Cox JA. "The binding of calcium to the B-repeat segment of SdrD, a cell surface protein of Staphylococcus aureus." J Biol Chem. 1998; 273(47): 31145-52., PMID: 9813018  
DP00066Region 1Choi HK, Tong L, Minor W, Dumas P, Boege U, Rossmann MG, Wengler G. "Structure of Sindbis virus core protein reveals a chymotrypsin-like serine proteinase and the organization of the virion." Nature. 1991; 354(6348): 37-43., PMID: 1944569  
DP00067Region 1Kim KK, Kim R, Kim SH. "Crystal structure of a small heat-shock protein." Nature. 1998; 394(6693): 595-9., PMID: 9707123  
DP00068 Brunger AT. "Structural insights into the molecular mechanism of Ca(2+)-dependent exocytosis." Curr Opin Neurobiol. 2000; 10(3): 293-302., PMID: 10851178  
 Region 1Fasshauer, D. Eliason, W. K. Brunger, A. T. Jahn, R. "Identification of a minimal core of the synaptic SNARE complex sufficient for reversible assembly and disassembly." Biochemistry. 1998; 37(29): 10354-10362., PMID: 9671503  
DP00069Region 3Canaves JM, Montal M. "Assembly of a ternary complex by the predicted minimal coiled-coil-forming domains of syntaxin, SNAP-25, and synaptobrevin. A circular dichroism study." J Biol Chem. 1998; 273(51): 34214-34221., PMID: 9852083  
 Region 1Fasshauer D, Otto H, Eliason WK, Jahn R, Brunger AT. "Structural changes are associated with soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor complex formation." J Biol Chem. 1997; 272(44): 28036-28041., PMID: 9346956 brunger@stanford.edu
 Region 2Hazzard J, Sudhof TC, Rizo J. "NMR analysis of the structure of synaptobrevin and of its interaction with syntaxin." J Biomol NMR. 1999; 14(3): 203-207., PMID: 10481273  
DP00070Region 1Weinreb, P. H. Zhen, W. Poon, A. W. Conway, K. A. Lansbury, P. T., Jr. "NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded." Biochemistry. 1996; 35(43): 13709-13715., PMID: 8901511  
 Region 1Nielsen, M. S. Vorum, H. Lindersson, E. Jensen, P. H. "Ca2+ binding to alpha-synuclein regulates ligand binding and oligomerization." J Biol Chem. 2001; 276(25): 22680-22684., PMID: 11312271  
 Region 1Eliezer D, Kutluay E, Bussell R Jr, Browne G. "Conformational properties of alpha-synuclein in its free and lipid-associated states." J Mol Biol. 2001; 307(4): 1061-73., PMID: 11286556 dae2005@mail.med.cor
nell.edu
 Region 1Bussell R Jr, Eliezer D. "Residual structure and dynamics in Parkinson's disease-associated mutants of alpha-synuclein." J Biol Chem. 2001; 276(49): 45996-6003., PMID: 11590151  
DP00071Region 1, Region 2, Region 3Tell G, Perrone L, Fabbro D, Pellizzari L, Pucillo C, De Felice M, Acquaviva R, Formisano S, Damante G. "Structural and functional properties of the N transcriptional activation domain of thyroid transcription factor-1: similarities with the acidic activation domains." Biochem J. 1998; 329 ( Pt 2): 395-403., PMID: 9425125  
DP00072 Helmes M, Trombitas K, Centner T, Kellermayer M, Labeit S, Linke WA, Granzier H. "Mechanically driven contour-length adjustment in rat cardiac titin's unique N2B sequence: titin is an adjustable spring." Circ Res. 1999; 84(11): 1339-52., PMID: 10364572  
  Kellermayer MS, Smith SB, Granzier HL, Bustamante C. "Folding-unfolding transitions in single titin molecules characterized with laser tweezers." Science. 1997; 276(5315): 1112-6., PMID: 9148805  
  Ma K, Kan L, Wang K. "Polyproline II helix is a key structural motif of the elastic PEVK segment of titin." Biochemistry. 2001; 40(12): 3427-38., PMID: 11297408  
 Region 1Labeit S, Kolmerer B. "Titins: giant proteins in charge of muscle ultrastructure and elasticity." Science. 1995; 270(5234): 293-6., PMID: 7569978 labeit@embl-heidelbe
rg.de
 Region 1Trombitas K, Greaser M, Labeit S, Jin JP, Kellermayer M, Helmes M, Granzier H. "Titin extensibility in situ: entropic elasticity of permanently folded and permanently unfolded molecular segments." J Cell Biol. 1998; 140(4): 853-9., PMID: 9472037  
DP00073Region 1, Region 2, Region 3Schiffer CA, Clifton IJ, Davisson VJ, Santi DV, Stroud RM. "Crystal structure of human thymidylate synthase: a structural mechanism for guiding substrates into the active site." Biochemistry. 1995; 34(50): 16279-87., PMID: 8845352  
 Region 4Phan J, Steadman DJ, Koli S, Ding WC, Minor W, Dunlap RB, Berger SH, Lebioda L. "Structure of human thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors." J Biol Chem. 2001; 276(17): 14170-7., PMID: 11278511  
DP00074 Krust A, Green S, Argos P, Kumar V, Walter P, Bornert JM, Chambon P. "The chicken oestrogen receptor sequence: homology with v-erbA and the human oestrogen and glucocorticoid receptors." Embo J. 1986; 5(5): 891-7., PMID: 3755102  
 Region 1Warnmark A, Wikstrom A, Wright AP, Gustafsson JA, Hard T. "The N-terminal regions of estrogen receptor alpha and beta are unstructured in vitro and show different TBP binding properties." J Biol Chem. 2001; 276(49): 45939-44., PMID: 11595744  
 Region 2, Region 3Schwabe JW, Chapman L, Finch JT, Rhodes D, Neuhaus D. "DNA recognition by the oestrogen receptor: from solution to the crystal." Structure. 1993; 1(3): 187-204., PMID: 16100953  
DP00075Region 1, Region 2, Region 3, Region 4Bharti AK, Olson MO, Kufe DW, Rubin EH. "Identification of a nucleolin binding site in human topoisomerase I." J Biol Chem. 1996; 271(4): 1993-1997., PMID: 8567649  
 Region 3, Region 4Christensen MO, Barthelmes HU, Boege F, Mielke C. "Residues 190-210 of human topoisomerase I are required for enzyme activity in vivo but not in vitro." Nucleic Acids Res. 2003; 31(24): 7255-7263., PMID: 14654701  
 Region 3, Region 4Frohlich RF, Andersen FF, Westergaard O, Andersen AH, Knudsen BR. "Regions within the N-terminal domain of human topoisomerase I exert important functions during strand rotation and DNA binding." J Mol Biol. 2004; 336(1): 93-103., PMID: 14741206  
 Region 2Labourier E, Rossi F, Gallouzi IE, Allemand E, Divita G, Tazi J. "Interaction between the N-terminal domain of human DNA topoisomerase I and the arginine-serine domain of its substrate determines phosphorylation of SF2/ASF splicing factor." Nucleic Acids Res. 1998; 26(12): 2955-2962., PMID: 9611241  
 Region 3, Region 4Lisby M, Olesen JR, Skouboe C, Krogh BO, Straub T, Boege F, Velmurugan S, Martensen PM, Andersen AH, Jayaram M, Westergaard O, Knudsen BR. "Residues within the N-terminal domain of human topoisomerase I play a direct role in relaxation." J Biol Chem. 2001; 276(23): 20220-20227., PMID: 11283003  
 Region 3, Region 6, Region 9, Region 10, Region 12Redinbo MR, Stewart L, Kuhn P, Champoux JJ, Hol WG. "Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA." Science. 1998; 279(5356): 1504-1153., PMID: 9488644  
 Region 7, Region 13, Region 14, Region 15, Region 16, Region 17, Region 18, Region 19, Region 20, Region 21, Region 22, Region 23, Region 24Redinbo MR, Stewart L, Champoux JJ, Hol WG. "Structural flexibility in human topoisomerase I revealed in multiple non-isomorphous crystal structures." J Mol Biol. 1999; 292(3): 685-696., PMID: 10497031  
 Region 1, Region 2Shaiu WL, Hu T, Hsieh TS. "The hydrophilic, protease-sensitive terminal domains of eucaryotic DNA topoisomerases have essential intracellular functions." Pac Symp Biocomput. 1999: 578-589., PMID: 10380229  
 Region 1, Region 2Stewart L, Ireton GC, Parker LH, Madden KR, Champoux JJ. "Biochemical and biophysical analyses of recombinant forms of human topoisomerase I." J Biol Chem. 1996; 271(13): 7593-7601., PMID: 8631793  
 Region 2Stewart L, Ireton GC, Champoux JJ. "The domain organization of human topoisomerase I." J Biol Chem. 1996; 271(13): 7602-7608., PMID: 8631794  
 Region 4, Region 5, Region 7, Region 8, Region 11Stewart L, Redinbo MR, Qiu X, Hol WG, Champoux JJ. "A model for the mechanism of human topoisomerase I." Science. 1998; 279(5356): 1534-1541., PMID: 9488652  
DP00076Region 11Berger, J.M. Personal communication. . 
 Region 1, Region 2, Region 3, Region 4, Region 5, Region 6, Region 7, Region 8, Region 9, Region 10Berger JM, Gamblin SJ, Harrison SC, Wang JC. "Structure and mechanism of DNA topoisomerase II." Nature. 1996; 379(6562): 225-32., PMID: 8538787  
DP00077 Hartshorne TA, Blumberg H, Young ET. "Sequence homology of the yeast regulatory protein ADR1 with Xenopus transcription factor TFIIIA." Nature. 1986; 320(6059): 283-7., PMID: 3515197  
 Region 1, Region 2Hyre DE, Klevit RE. "A disorder-to-order transition coupled to DNA binding in the essential zinc-finger DNA-binding domain of yeast ADR1." Journal of Molecular Biology. 1998; 279(4): 929-943., PMID: 9642072  
 Region 1, Region 2Hartshorne TA, Blumberg H, Young ET. "Sequence homology of the yeast regulatory protein ADR1 with Xenopus transcription factor TFIIIA." Nature. 1986; 320(6059): 283-7., PMID: 3515197  
DP00078Region 1Campbell KM, Terrell AR, Laybourn PJ, Lumb KJ. "Intrinsic structural disorder of the C-terminal activation domain from the bZIP transcription factor Fos." Biochemistry. 2000; 39(10): 2708-2713., PMID: 10704222  
 Region 1Flaugh SL, Lumb KJ. "Effects of macromolecular crowding on the intrinsically disordered proteins c-Fos and p27(Kip1)." Biomacromolecules. 2001; 2(2): 538-540., PMID: 11749217  
DP00079Region 1Warnmark A, Wikstrom A, Wright AP, Gustafsson JA, Hard T. "The N-terminal regions of estrogen receptor alpha and beta are unstructured in vitro and show different TBP binding properties." J Biol Chem. 2001; 276(49): 45939-44., PMID: 11595744  
DP00080 Gonzales G, Yamamoto K, Fischer W, Karr D, Menzel P, Biggs W, Vale W, Montminy M. "A cluster of phosphorylation sites on the cyclic AMP-regulated nuclear factor CREB predicted by its sequence." Nature. 1989; 337: 749-752. 
  Short ML, Manohar CF, Furtado MR, Ghadge GD, Wolinsky SM, Thimmapaya B, Jungmann RA. "Nucleotide and derived amino-acid sequences of the CRE-binding proteins from rat C6 glioma and HeLa cells." Nucleic Acids Res. 1991; 19(15): 4290., PMID: 1831258  
 Region 1, Region 2, Region 3Radhakrishnan I, Perez-Alvarado GC, Parker D, Dyson HJ, Montminy MR, Wright PE. "Solution structure of the KIX domain of CBP bound to the transactivation domain of CREB: a model for activator:coactivator interactions." Cell. 1997; 91(6): 741-752., PMID: 9413984  
 Region 2Radhakrishnan I, Perez-Alvarado GC, Dyson HJ, Wright PE. "Conformational preferences in the Ser133-phosphorylated and non-phosphorylated forms of the kinase inducible transactivation domain of CREB." FEBS Lett. 1998; 430(3): 317-322., PMID: 9688563  
DP00081 Liu D, Ishima R, Tong KI, Bagby S, Kokubo T, Muhandiram DR, Kay LE, Nakatani Y, Ikura M. "Solution structure of a TBP-TAF(II)230 complex: protein mimicry of the minor groove surface of the TATA box unwound by TBP." Cell. 1998; 94(5): 573-583., PMID: 9741622  
 Region 1Liu D, Ishima R, Tong KI, Bagby S, Kokubo T, Muhandiram DR, Kay LE, Nakatani Y, Ikura M. "Solution structure of a TBP-TAF(II)230 complex: protein mimicry of the minor groove surface of the TATA box unwound by TBP." Cell. 1998; 94(5): 573-583., PMID: 9741622  
DP00082Region 1Hershey PE, McWhirter SM, Gross JD, Wagner G, Alber T, Sachs AB. "The Cap-binding protein eIF4E promotes folding of a functional domain of yeast translation initiation factor eIF4G1." J Biol Chem. 1999; 274(30): 21297-304., PMID: 10409688  
DP00083Region 1Weiss MA, Ellenberger T, Wobbe CR, Lee JP, Harrison SC, Struhl K. "Folding transition in the DNA-binding domain of GCN4 on specific binding to DNA." Nature. 1990; 347(6293): 575-8., PMID: 2145515  
DP00084 Pursglove SE, Fladvad M, Bellanda M, Moshref A, Henriksson M, Carey J, Sunnerhagen M. "Biophysical properties of regions flanking the bHLH-Zip motif in the p22 Max protein." Biochem Biophys Res Commun. 2004; 323(3): 750-9., PMID: 15381064  
  Sauve S, Tremblay L, Lavigne P. "The NMR solution structure of a mutant of the Max b/HLH/LZ free of DNA: insights into the specific and reversible DNA binding mechanism of dimeric transcription factors." J Mol Biol. 2004; 342(3): 813-32., PMID: 15342239  
  Ferre-D'Amare AR, Pognonec P, Roeder RG, Burley SK. "Structure and function of the b/HLH/Z domain of USF." Embo J. 1994; 13(1): 180-9., PMID: 8306960  
 Region 1Horiuchi M, Kurihara Y, Katahira M, Maeda T, Saito T, Uesugi S. "Dimerization and DNA binding facilitate alpha-helix formation of Max in solution." J Biochem (Tokyo). 1997; 122(4): 711-6., PMID: 9399572  
DP00084_A001Region 1, Region 2Naud JF, McDuff FO, Sauve S, Montagne M, Webb BA, Smith SP, Chabot B, Lavigne P. "Structural and Thermodynamical Characterization of the Complete p21 Gene Product of Max." Biochemistry. 2005; 44(38): 12746-12758., PMID: 16171389 Pierre.Lavigne@Usher
brooke.ca
DP00085 Ruben SM, Dillon PJ, Schreck R, Henkel T, Chen CH, Maher M, Baeuerle PA, Rosen CA. "Isolation of a rel-related human cDNA that potentially encodes the 65-kD subunit of NF-kappa B." Science. 1991; 251(5000): 1490-1493., PMID: 2006423  
 Region 1, Region 2Schmitz ML, Baeuerle PA. "The p65 subunit is responsible for the strong transcription activating potential of NF-kappa B." Embo J. 1991; 10(12): 3805-3817., PMID: 1935902  
 Region 1, Region 2, Region 3Schmitz ML, dos Santos Silva MA, Altmann H, Czisch M, Holak TA, Baeuerle PA. "Structural and functional analysis of the NF-kappa B p65 C terminus. An acidic and modular transactivation domain with the potential to adopt an alpha-helical conformation." J Biol Chem. 1994; 269(41): 25613-25620., PMID: 7929265  
DP00086 Soussi T, Caron de Fromentel C, May P. "Structural aspects of the p53 protein in relation to gene evolution." Oncogene. 1990; 5(7): 945-52., PMID: 2142762  
 Region 1Chang J, Kim DH, Lee SW, Choi KY, Sung YC. "Transactivation ability of p53 transcriptional activation domain is directly related to the binding affinity to TATA-binding protein." J Biol Chem. 1995; 270(42): 25014-9., PMID: 7559631  
 Region 7Joerger AC, Allen MD, Fersht AR. "Crystal structure of a superstable mutant of human p53 core domain. Insights into the mechanism of rescuing oncogenic mutations." J Biol Chem. 2004; 279(2): 1291-6., PMID: 14534297  
 Region 2, Region 3Kussie PH, Gorina S, Marechal V, Elenbaas B, Moreau J, Levine AJ, Pavletich NP. "Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain." Science. 1996; 274(5289): 948-53., PMID: 8875929  
 Region 8, Region 9Kuszewski J, Gronenborn AM, Clore GM. "Improving the packing and accuracy of NMR structures with a pseudopotential for the radius of gyration." Journal of the American Chemicial Society. 1999; 121(10): 2337-2338. 
 Region 4, Region 5, Region 6Derbyshire DJ, Basu BP, Date T, Iwabuchi K, Doherty AJ. "Purification, crystallization and preliminary X-ray analysis of the BRCT domains of human 53BP1 bound to the p53 tumour suppressor." Acta Crystallogr D Biol Crystallogr. 2002; 58(Pt 10 Pt 2): 1826-9., PMID: 12351827  
 Region 4, Region 5, Region 6Derbyshire DJ, Basu BP, Serpell LC, Joo WS, Date T, Iwabuchi K, Doherty AJ. "Crystal structure of human 53BP1 BRCT domains bound to p53 tumour suppressor." Embo J. 2002; 21(14): 3863-72., PMID: 12110597  
DP00087 Donaldson L, Capone JP. "Purification and characterization of the carboxyl-terminal transactivation domain of Vmw65 from herpes simplex virus type 1." J Biol Chem. 1992; 267(3): 1411-4., PMID: 1309782  
  Hayes Steven, O'Hare P. "Mapping of a major surface-exposed site in herpes simplex virus protein Vmw65 to a region of direct interaction in a transcription complex assembly." Journal of Virology. 1992; 67(2): 852-862. 
  O'Hare P, Williams G. "Structural studies of the acidic transactivation domain of the Vmw65 protein of herpes simplex virus using 1H NMR." Biochemistry. 1992; 31(16): 4150-6., PMID: 1314658  
  Shen F, Triezenberg SJ, Hensley P, Porter D, Knutson JR. "Critical amino acids in the transcriptional activation domain of the herpesvirus protein VP16 are solvent-exposed in highly mobile protein segments. An intrinsic fluorescence study." J Biol Chem. 1996; 271(9): 4819-26., PMID: 8617751  
  Uesugi M, Nyanguile O, Lu H, Levine AJ, Verdine GL. "Induced alpha helix in the VP16 activation domain upon binding to a human TAF." Science. 1997; 277(5330): 1310-3., PMID: 9271577  
 Region 1, Region 2Liu Y, Gong W, Huang CC, Herr W, Cheng X. "Crystal structure of the conserved core of the herpes simplex virus transcriptional regulatory protein VP16." Genes Dev. 1999; 13(13): 1692-703., PMID: 10398682  
DP00088 Wilmanns M, Lappalainen P, Kelly M, Sauer-Eriksson E, Saraste M. "Crystal structure of the membrane-exposed domain from a respiratory quinol oxidase complex with an engineered dinuclear copper center." Proc Natl Acad Sci U S A. 1995; 92(26): 11955-9., PMID: 8618822  
 Region 1, Region 2, Region 3, Region 4, Region 5Abramson J, Riistama S, Larsson G, Jasaitis A, Svensson-Ek M, Laakkonen L, Puustinen A, Iwata S, Wikstrom M. "The structure of the ubiquinol oxidase from Escherichia coli and its ubiquinone binding site." Nat Struct Biol. 2000; 7(10): 910-7., PMID: 11017202  
 Region 1, Region 2, Region 3, Region 4, Region 5Chepuri V, Lemieux L, Au DC, Gennis RB. "The sequence of the cyo operon indicates substantial structural similarities between the cytochrome o ubiquinol oxidase of Escherichia coli and the aa3-type family of cytochrome c oxidases." J Biol Chem. 1990; 265(19): 11185-92., PMID: 2162835  
DP00089 Chepuri V, Lemieux L, Au DC, Gennis RB. "The sequence of the cyo operon indicates substantial structural similarities between the cytochrome o ubiquinol oxidase of Escherichia coli and the aa3-type family of cytochrome c oxidases." J Biol Chem. 1990; 265(19): 11185-92., PMID: 2162835  
 Region 1, Region 2Abramson J, Riistama S, Larsson G, Jasaitis A, Svensson-Ek M, Laakkonen L, Puustinen A, Iwata S, Wikstrom M. "The structure of the ubiquinol oxidase from Escherichia coli and its ubiquinone binding site." Nat Struct Biol. 2000; 7(10): 910-7., PMID: 11017202  
 Region 3, Region 4van der Oost J, Lappalainen P, Musacchio A, Warne A, Lemieux L, Rumbley J, Gennis RB, Aasa R, Pascher T, Malmstrom BG, et al. "Restoration of a lost metal-binding site: construction of two different copper sites into a subunit of the E. coli cytochrome o quinol oxidase complex." Embo J. 1992; 11(9): 3209-17., PMID: 1324168  
 Region 3, Region 4van der Oost J, Musacchio A, Pauptit RA, Ceska TA, Wierenga RK, Saraste M. "Crystallization and preliminary X-ray analysis of the periplasmic fragment of CyoA-a subunit of the Escherichia coli cytochrome o complex." J Mol Biol. 1993; 229(3): 794-6., PMID: 8433374  
 Region 3, Region 4Wilmanns M, Lappalainen P, Kelly M, Sauer-Eriksson E, Saraste M. "Crystal structure of the membrane-exposed domain from a respiratory quinol oxidase complex with an engineered dinuclear copper center." Proc Natl Acad Sci U S A. 1995; 92(26): 11955-9., PMID: 8618822  
DP00090Region 1Wissmann R, Baukrowitz T, Kalbacher H, Kalbitzer HR, Ruppersberg JP, Pongs O, Antz C, Fakler B. "NMR structure and functional characteristics of the hydrophilic N terminus of the potassium channel beta-subunit Kvbeta1.1." J Biol Chem. 1999; 274(50): 35521-5., PMID: 10585425  
DP00091Region 1, Region 2Iakoucheva LM, Kimzey AL, Masselon CD, Bruce JE, Garner EC, Brown CJ, Dunker AK, Smith RD, Ackerman EJ. "Identification of intrinsic order and disorder in the DNA repair protein XPA." Protein Sci. 2001; 10(3): 560-71., PMID: 11344324 eric.ackerman@pnl.go
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DP00092 Muramatsu T, Kincaid RL. "Molecular cloning of a full-length cDNA encoding the catalytic subunit of human calmodulin-dependent protein phosphatase (calcineurin A alpha)." Biochim Biophys Acta. 1993; 1178(1): 117-20., PMID: 8392375  
 Region 1, Region 2, Region 3, Region 4, Region 5, Region 6Kissinger CR, Parge HE, Knighton DR, Lewis CT, Pelletier LA, Tempczyk A, Kalish VJ, Tucker KD, Showalter RE, Moomaw EW, et al. "Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex." Nature. 1995; 378(6557): 641-4., PMID: 8524402  
DP00092_A001Region 1, Region 2Jin L, Harrison SC. "Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin." Proc Natl Acad Sci U S A. 2002; 99(21): 13522-6., PMID: 12357034  
 Region 1Kissinger CR, Parge HE, Knighton DR, Lewis CT, Pelletier LA, Tempczyk A, Kalish VJ, Tucker KD, Showalter RE, Moomaw EW, et al. "Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex." Nature. 1995; 378(6557): 641-4., PMID: 8524402  
DP00093Region 1Garboczi DN, Ghosh P, Utz U, Fan QR, Biddison WE, Wiley DC. "Structure of the complex between human T-cell receptor, viral peptide and HLA-A2." Nature. 1996; 384(6605): 134-41., PMID: 8906788  
DP00094 Goodwill KE, Sabatier C, Marks C, Raag R, Fitzpatrick PF, Stevens RC. "Crystal structure of tyrosine hydroxylase at 2.3 A and its implications for inherited neurodegenerative diseases." Nat Struct Biol. 1997; 4(7): 578-85., PMID: 9228951  
 Region 1Daubner SC, Lohse DL, Fitzpatrick PF. "Expression and characterization of catalytic and regulatory domains of rat tyrosine hydroxylase." Protein Sci. 1993; 2(9): 1452-60., PMID: 8104613  
DP00095Region 1Brick P, Bhat TN, Blow DM. "Structure of tyrosyl-tRNA synthetase refined at 2.3 A resolution. Interaction of the enzyme with the tyrosyl adenylate intermediate." J Mol Biol. 1989; 208(1): 83-98., PMID: 2504923  
 Region 1Guijarro JI, Pintar A, Prochnicka-Chalufour A, Guez V, Gilquin B, Bedouelle H, Delepierre M. "Structure and dynamics of the anticodon arm binding domain of Bacillus stearothermophilus Tyrosyl-tRNA synthetase." Structure (Camb). 2002; 10(3): 311-7., PMID: 12005430  
DP00096Region 1McManus E, Luisi BF, Perham RN. "Structure of a putative lipoate protein ligase from Thermoplasma acidophilum and the mechanism of target selection for post-translational modification." J Mol Biol. 2006; 356(3): 625-37., PMID: 16384580  
DP00097Region 3Roque A, Iloro I, Ponte I, Arrondo JL, Suau P. "DNA-induced secondary structure of the carboxyl-terminal domain of histone H1." J Biol Chem. 2005; 280(37): 32141-7., PMID: 16006555 pere.suau@uab.es
 Region 4Vila R, Ponte I, Jimenez MA, Rico M, Suau P. "A helix-turn motif in the C-terminal domain of histone H1." Protein Sci. 2000; 9(4): 627-36., PMID: 10794405